A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer

Sponsor: Bristol-Myers Squibb

Sponsor score: 60

ClinicalTrials ID:NCT07325136

This clinical trial evaluates the safety and tolerability of BMS-986525, alone and with Nivolumab, in patients with relapsed/refractory small cell lung cancer. Participants receive specified doses of BMS-986525 and Nivolumab on designated days. Eligibility criteria include prior treatment history and specific health conditions. The study aims to determine optimal dosing and potential side effects.

Patient Parameters

Program Overview

The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Nivolumab in participants with Relapsed/Refractory Small Cell Lung Cancer

Eligibility Criteria

Inclusion Criteria

  • Participants must have histologically or cytologically documented relapsed/refractory small cell lung cancer (R/R-SCLC).
  • Participants must have received at least 1 platinum-based chemotherapy regimen as per locally approved drug labels and institutional guidelines.
  • In countries where standard of care first line systemic treatment includes platinum containing chemotherapy in combination with anti-PD-(L)1 therapy, it is required that participants have progressed on, are ineligible for or not have access to an anti-PD- (L)1 therapy.

Exclusion Criteria

  • Participants must not have any untreated CNS metastases.
  • Participants must not have an active, known or suspected autoimmune disease.
  • Participants must not have had a prior organ or tissue allograft.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Locations

FACILITYZIPCITYSTATE
Local Institution - 001148201DetroitMichigan
Local Institution - 002614263BuffaloNew York
Duke Cancer Institute27710DurhamNorth Carolina
University Hospitals Cleveland Medical Center44106ClevelandOhio
SCRI Oncology Partners37203NashvilleTennessee

Get This Program In Your Inbox

You can sign up and apply your patients for this program.