A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer
Sponsor: Bristol-Myers Squibb
Sponsor score: 60
ClinicalTrials ID:NCT07325136
This clinical trial evaluates the safety and tolerability of BMS-986525, alone and with Nivolumab, in patients with relapsed/refractory small cell lung cancer. Participants receive specified doses of BMS-986525 and Nivolumab on designated days. Eligibility criteria include prior treatment history and specific health conditions. The study aims to determine optimal dosing and potential side effects.
Patient Parameters
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Program Overview
The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Nivolumab in participants with Relapsed/Refractory Small Cell Lung Cancer
Eligibility Criteria
Inclusion Criteria
- Participants must have histologically or cytologically documented relapsed/refractory small cell lung cancer (R/R-SCLC).
- Participants must have received at least 1 platinum-based chemotherapy regimen as per locally approved drug labels and institutional guidelines.
- In countries where standard of care first line systemic treatment includes platinum containing chemotherapy in combination with anti-PD-(L)1 therapy, it is required that participants have progressed on, are ineligible for or not have access to an anti-PD- (L)1 therapy.
Exclusion Criteria
- Participants must not have any untreated CNS metastases.
- Participants must not have an active, known or suspected autoimmune disease.
- Participants must not have had a prior organ or tissue allograft.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Local Institution - 0011 | 48201 | Detroit | Michigan |
| Local Institution - 0026 | 14263 | Buffalo | New York |
| Duke Cancer Institute | 27710 | Durham | North Carolina |
| University Hospitals Cleveland Medical Center | 44106 | Cleveland | Ohio |
| SCRI Oncology Partners | 37203 | Nashville | Tennessee |
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