A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Sponsor: Eli Lilly and Company
ClinicalTrials ID:NCT06876662
This study, an extension of the originator study LOXO-BTK-18001, focuses on participants with chronic lymphocytic leukemia/small lymphocytic lymphoma or non-Hodgkin lymphoma. Eligible participants are those active in the originator study, either receiving pirtobrutinib or in follow-up phases. The trial assesses the long-term safety and efficacy of orally administered pirtobrutinib.
Patient Parameters
| Parameter | Options |
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Program Overview
Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this study. This study will evaluate the long-term safety and efficacy of pirtobrutinib.
Eligibility Criteria
Inclusion Criteria
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Are currently enrolled and active in the originator study, 18001. A participant is considered active in the study if they are:
- receiving study intervention
- in the short-term follow-up period, or
- in the long-term follow-up period.
Exclusion Criteria
- Were a participant in the Phase 1b cohort of Study 18001.
- Are pregnant or intend to become pregnant during the study or within 30 days of last dose of study treatment or intend to breastfeed during the study or within 1 week of the last dose of study treatment.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Sylvester Comprehensive Cancer Center | 33136-1002 | Miami | Florida |
| Florida Cancer Specialists | 34232-6422 | Sarasota | Florida |
| The Emory Clinic | 30322-1013 | Atlanta | Georgia |
| Northwestern University | 60611-3013 | Chicago | Illinois |
| Dana-Farber Cancer Institute | 02115 | Boston | Massachusetts |
| Mayo Clinic- Minnesota | 55905 | Rochester | Minnesota |
| University Of Nebraska Medical Center | 69198 | Omaha | Nebraska |
| Northwell Health | 11042-1118 | Lake Success | New York |
| Memorial Sloan-Kettering Cancer Center (MSKCC) - New York | 10065-6007 | New York | New York |
| Duke University Medical Center | 27710-4000 | Durham | North Carolina |
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