A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Sponsor: Memorial Sloan Kettering Cancer Center
Sponsor score: 60
ClinicalTrials ID:NCT05419076
This study evaluates the effectiveness of SRS in treating brain metastases from SCLC. Eligible participants are adults with up to 10 brain metastases, a KPS of 60-100, and no prior brain radiotherapy. Interventions include MSK standard SRS and cerebrospinal fluid collection via lumbar puncture. Exclusions include inability to undergo MRI and confirmed leptomeningeal disease.
Patient Parameters
| Parameter | Options |
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Program Overview
The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.
Eligibility Criteria
Inclusion Criteria
- Histologic diagnosis of small cell lung cancer
- Radiographic diagnosis of up to 10 brain metastases on contrast-enhanced MRI
- Age 18 and above
- Performance status KPS 60-100/ECOG 0-2
- Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
- The patient or legally authorized representative is able to provide informed consent
Exclusion Criteria
- Unable to undergo contrast-enhanced MRI brain or spine
- Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
- Pregnant or lactating women
- Prior brain-directed radiotherapy
- Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Hartford Healthcare (Data Collection Only) | 06102 | Hartford | Connecticut |
| Memorial Sloan Kettering at Basking Ridge | 07920 | Basking Ridge | New Jersey |
| Memorial Sloan Kettering Monmouth | 07748 | Middletown | New Jersey |
| Memorial Sloan Kettering Bergen | 07645 | Montvale | New Jersey |
| Memorial Sloan Kettering Suffolk - Commack | 11725 | Commack | New York |
| Memorial Sloan Kettering Westchester | 10604 | Harrison | New York |
| Memorial Sloan Kettering Cancer Center (All Protocol Activities) | 10065 | New York | New York |
| Memorial Sloan Kettering Nassau | 11553 | Rockville Centre | New York |
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