Study on MK-2010 Alone and With Other Treatments for Advanced Solid Tumors

Inclusion Criteria

• Have a type of cancer that can be measured by scans or tests.
• Be able to swallow pills if the treatment is taken by mouth and have no digestive issues that affect absorption.
• Have well-controlled HIV if diagnosed, with ongoing antiretroviral therapy.
• Have good organ function as required by the study.

Exclusion Criteria

• Have a history of certain diseases like Kaposi's sarcoma or Multicentric Castleman's Disease if diagnosed with HIV.
• Have a history of brain conditions like posterior reversible encephalopathy syndrome or seizures.
• Have severe liver conditions or diseases affecting the brain due to liver issues.
• Have inflammatory bowel disease.
• Have serious wounds, ulcers, or bone fractures that are not healing.
• Have a history of heart inflammation or heart muscle disease.
• Have severe heart or blood vessel diseases.
• Be taking blood thinners.
• Have an immune system deficiency.
• Have another cancer that is growing or needed treatment in the last 3 years.
• Have cancer that has spread to the brain or spinal cord.
• Have an active autoimmune disease needing treatment in the last 2 years (except for hormone treatments like thyroxine or insulin).
• Have a history of lung inflammation needing steroids or current lung disease.
• Have had a stem cell or organ transplant.
• Have not fully recovered from major surgery or have ongoing surgical issues.