Study on UB-VV400 and Rapamycin for Treating Difficult B-cell Blood Cancers

Inclusion Criteria

• Must be 18 years or older.
• Must agree to participate and provide written consent.
• Have large B-cell lymphoma that has returned or not responded to treatment.
• Have cancer that can be measured using specific medical criteria.
• Cancer cells must show CD22 markers.
• Must not have serious other diseases or uncontrolled infections.
• Must be in good overall health with a performance status of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Must have adequate organ function.

Exclusion Criteria

• Women who are pregnant or breastfeeding cannot participate.
• Cannot have cancer that is only in the central nervous system (CNS).
• Cannot have had a previous bone marrow transplant from a donor, gene therapy, or certain types of cell transfers, except for specific exceptions like CAR T cells.
• Cannot have a history of or active HIV.
• Cannot have active or chronic hepatitis B or active hepatitis C.
• Cannot have systemic immune system diseases, except for well-controlled Type I diabetes or thyroid disease.
• Cannot have ongoing CNS disease that affects neurological assessment.
• Cannot have uncontrolled chest pain or other serious heart conditions.
• Cannot be participating in another clinical trial with interventions.