Study on Belzutifan and Zanzalintinib for Treating Advanced Kidney Cancer (Renal Cell Carcinoma)

Sponsor: Merck Sharp & Dohme LLC

Sponsor score: 40

ClinicalTrials ID:NCT07489495

Provider View

This clinical trial is exploring whether combining two targeted therapies, Belzutifan and Zanzalintinib, can improve outcomes for people with advanced kidney cancer compared to using Belzutifan alone.

Patient Parameters

Program Overview

Researchers are investigating new treatments for advanced kidney cancer, known as renal cell carcinoma (RCC). The study is testing whether adding a new targeted therapy, Zanzalintinib, to the existing treatment with Belzutifan can help more patients live longer and prevent the cancer from worsening, compared to using Belzutifan alone. Targeted therapies are designed to specifically attack cancer cells and stop them from growing and spreading.

Eligibility Criteria

Inclusion Criteria

  • Diagnosed with advanced kidney cancer (renal cell carcinoma) that cannot be removed by surgery, specifically Stage IV with clear cell features.
  • Have measurable cancer that can be tracked using standard criteria.
  • Have received no more than three previous treatments for kidney cancer, including only one treatment targeting specific immune checkpoints.

Exclusion Criteria

  • Have low oxygen levels at rest or need supplemental oxygen.
  • Have significant heart disease within the past year.
  • Have had a blood clot in a deep vein within the past three months unless stable and treated.
  • Have a heart pumping ability of 50% or lower.
  • Have had major surgery within the past eight weeks.
  • Have current lung inflammation or disease.
  • Have a history of HIV infection.
  • Have active Hepatitis B or C infection.
  • Have another active cancer that has required treatment in the past three years.
  • Have had a solid organ transplant.
  • Have not fully recovered from major surgery or have ongoing surgical issues.

Locations

FACILITYZIPCITYSTATE
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0102)30060MariettaGeorgia
The West Clinic, P.C. ( Site 0115)38138GermantownTennessee

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