Symbiotic-Lung-10: Study on PF-08634404 Alone or with Chemotherapy for Early-stage or Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria

• Must be 18 years or older.
• Have available tumor tissue from a biopsy.
• Have PD-L1 status results from local testing.
• Have healthy organs and good physical condition based on medical tests.
• Have an ECOG performance status score of 0 or 1, indicating full activity or some restriction in strenuous activities.
• Part A: Newly diagnosed, untreated early-stage or locally advanced NSCLC that can be removed by surgery, and eligible for neoadjuvant therapy.
• Part B: Early-stage or locally advanced NSCLC that has been surgically removed, eligible for adjuvant therapy, and did not achieve a complete response from prior treatment.
• Part C: Locally advanced NSCLC that cannot be removed by surgery, has received specific radiation and chemotherapy, and has not worsened.

Exclusion Criteria

• Have known changes in EGFR and ALK genes (for non-squamous NSCLC).
• Have cancer spread to the brain or spinal cord.
• Have a high risk of bleeding or fistula.
• Have had another cancer within the last 3 years or have residual disease from a previous cancer.
• Have unresolved side effects from previous cancer treatments.
• Have severe allergies to study medications.
• Have had an organ or stem cell transplant.
• Have certain lung diseases or severe lung conditions.
• Have uncontrolled health conditions like heart disease or diabetes.
• Have had major surgery within 4 weeks or minor surgery within 3 days before starting the study.
• Have a history of severe bleeding or blood clotting issues.
• Have certain gastrointestinal issues or infections like HIV, hepatitis B, or hepatitis C.
• Have a history of immune system problems.
• Have any medical or psychiatric conditions that could increase risks or make participation inappropriate.
• Are breastfeeding or unwilling to use contraception if of childbearing potential.