Study on Using Donor Memory-Like Natural Killer Cells for Treating Relapsed or Hard-to-Treat Neuroblastoma

Inclusion Criteria

• Aged between 1 and 39 years old.
• Diagnosed with neuroblastoma, confirmed by lab tests.
• Classified as high-risk neuroblastoma, even if initially considered low or intermediate risk but later reclassified.
• Cancer has returned or is not responding to treatment, including:
  • Cancer came back after finishing initial treatment.
  • Cancer is getting worse after starting standard treatment.
  • Cancer did not fully respond after at least four cycles of standard chemotherapy.
• Must have cancer that can be measured or detected by scans or tests within four weeks before joining the study.
• Must be in good enough health to participate, with a performance score above 50%.
• Must have good heart and lung function, with specific test results showing adequate levels.
• Must have good blood cell counts and not need recent blood transfusions, unless due to cancer in the bone marrow.
• Must have a suitable donor who is a close relative.

Exclusion Criteria

• Have an active, uncontrolled infection or received a live vaccine within 30 days before joining the study.
• Have serious heart problems, including low heart function or history of heart failure.
• Have lung disease or history of lung problems needing steroid treatment.
• Have poor kidney function based on specific tests.
• Have severe liver problems, with high bilirubin or liver enzyme levels.
• Taking more than 0.5 mg/kg of prednisone or equivalent daily.
• Have received other experimental treatments within 30 days before the study treatment.
• Have an allergy to IL-2 injections.
• Are pregnant or breastfeeding.