Study on KK2430 for Treating Blood Cancers

Inclusion Criteria

• Must be 18 years or older.
• Have at least one measurable disease based on a CT scan or MRI.
• Have acceptable kidney function.
• Have an ECOG performance status score of 0, 1, or 2, indicating full activity or some restriction in strenuous activities.
• Be willing to provide a fresh tissue sample if the cancer has returned.
• Meet specific laboratory test values for blood counts, liver function, and other health indicators.
• Agree to use effective contraception if of childbearing potential or fertile.
• Be able to give informed consent and allow access to personal health information.
• Not be under any legal or institutional restrictions.

Exclusion Criteria

• Have certain medical conditions.
• Have had a previous allogenic transplant.
• Have Grade 2 peripheral neuropathy with pain.
• Have significant heart problems.
• Have active central nervous system involvement or signs of meningeal involvement.
• Have evidence of HIV infection.
• Have active chronic hepatitis B or C infection.
• Have received any anti-cancer treatment within three weeks or less before the screening visit.
• Have unresolved side effects from previous cancer treatments, except for hair loss and mild nerve damage without pain.
• Use systemic corticosteroids exceeding 10 mg/day of prednisone or equivalent within 14 days before the first dose.