Study on Cevostamab with Pomalidomide and Dexamethasone Compared to Standard Treatment for Previously Treated Multiple Myeloma

Sponsor: Hoffmann-La Roche

Sponsor score: 40

ClinicalTrials ID:NCT07555938

This clinical trial is testing a new combination of drugs, cevostamab with pomalidomide and dexamethasone, against the standard treatment for patients with multiple myeloma who have already received one to three previous treatments.

Patient Parameters

Program Overview

The aim of this study is to evaluate how well a new drug combination—cevostamab, pomalidomide, and dexamethasone—works compared to the usual treatment for people with multiple myeloma. This study is for patients who have already tried one to three different treatments and have been treated with an anti-CD38 antibody and lenalidomide.

Eligibility Criteria

Inclusion Criteria

  • Have a performance status score of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
  • If performance status is 2, it must be due to local symptoms of myeloma, like pain.
  • Diagnosed with multiple myeloma according to specific medical criteria.
  • Have received one to three previous treatments, including at least two cycles of a treatment with an anti-CD38 therapy or lenalidomide.
  • Have measurable disease at the time of screening.

Exclusion Criteria

  • Have a known history of amyloidosis, a condition where abnormal proteins build up in tissues and organs.
  • Have plasma cell leukemia or a high number of plasma cells in the blood.
  • Have gastrointestinal disease that could affect how oral drugs are absorbed.
  • Have any ongoing central nervous system disease or a type of myeloma that does not produce a detectable protein.

Locations

FACILITYZIPCITYSTATE
City of Hope National Medical Center91010-3012DuarteCalifornia
City of Hope - Lennar Foundation Cancer Center92618IrvineCalifornia
Winship Cancer Institute of Emory University30329AtlantaGeorgia

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