Study Comparing Two Boost Methods in Radiation Therapy for Prostate Cancer

Inclusion Criteria

• Diagnosed with intermediate-risk prostate cancer, specifically grade group 2 or 3, with certain cancer patterns found only in MRI scans.
• Prostate gland size must be 80 cc or smaller.
• MRI results must show no advanced disease beyond a certain stage.
• International Prostate Symptom Score (IPSS) must be less than 20.
• No medical reasons preventing the use of IRE, radiation therapy, anesthesia, or the transperineal procedure.

Exclusion Criteria

• Have a more advanced grade of prostate cancer or specific types of cancer cells.
• Evidence of cancer spread to lymph nodes or other parts of the body on imaging tests.
• Not suitable for general anesthesia or have allergies to necessary medications.
• Have an active urinary tract infection that must be treated before the procedure.
• Have bleeding issues or cannot safely stop blood thinners for the procedure.
• Have a history of heart rhythm problems, epilepsy, or recent heart attack.
• Have an implanted electronic device like a pacemaker that is not compatible with the procedure.
• Cannot undergo an MRI scan of the pelvis.
• Have had previous treatments for prostate cancer, such as hormone therapy, focal therapy, radiation, or surgery.
• Currently using or planning to use hormone therapy for prostate cancer.