Study on KQB198 and Imatinib for Treating Advanced or Metastatic Gastrointestinal Stromal Tumors (GIST)
Sponsor: Kumquat Biosciences Inc.
ClinicalTrials ID:NCT07406633
This clinical trial is testing a new drug, KQB198, in combination with an existing cancer treatment, imatinib, to see if it is safe and effective for patients with advanced or metastatic Gastrointestinal Stromal Tumors (GIST).
Patient Parameters
| Parameter | Options |
|---|
Program Overview
The purpose of this study is to evaluate the safety and effectiveness of a new drug called KQB198 when used together with imatinib, a medication already approved by the FDA for treating various cancers, including GIST. Researchers aim to find out if this combination can help treat patients with advanced or metastatic GIST, which is a type of cancer that occurs in the digestive tract.
Eligibility Criteria
Inclusion Criteria
All Participants:
- Unresectable or metastatic disease
- Tissue confirmation of GIST
- Valid results from local testing of blood or tumor tissue documenting the presence of a KIT mutation (must not have exon 9 mutation) or PDGFRA mutation (must not have PDGFRA D842V).
- Measurable disease per RECIST v1.1.
- Patients must be in 1st line of treatment for advanced or metastatic disease. Prior imatinib is allowed in adjuvant or neoadjuvant setting, as long as imatinib was stopped over 1 year ago.
- Adequate organ function and performance status
Exclusion Criteria
Participants are excluded from the study if any of the following criteria apply:
- Unable to swallow or GI condition that prevents absorption.
- Other active malignancies within the last 2 years.
- History of hypersensitivity to any component of KQB198 or imatinib.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| USC Norris Comprehensive Cancer Center | 90033 | Los Angeles | California |
| Mayo Clinic - Jacksonville | 32224 | Jacksonville | Florida |
| Moffitt Cancer Center | 33612 | Tampa | Florida |
| University of Michigan Hospitals | 48109 | Ann Arbor | Michigan |
| Mayo Clinic - Rochester | 55905 | Rochester | Minnesota |
| Cleveland Clinic | 44195 | Cleveland | Ohio |
| UT MD Anderson Cancer Center | 77030 | Houston | Texas |
| Fred Hutchinson Cancer Center | 98195 | Seattle | Washington |
Get This Program In Your Inbox
Receive detailed information about this treatment opportunity to review with your healthcare provider.