Study on PF-08634404 for Advanced Liver Cancer (Hepatocellular Carcinoma)

Inclusion Criteria

• Be 18 years or older.
• Have advanced liver cancer (HCC) that has spread locally or to other parts of the body, confirmed by medical tests.
• The cancer cannot be completely removed by surgery or has worsened after surgery or other local treatments.
• Have at least one measurable tumor that has not been treated.
• Have good liver and kidney function.
• Have not received any previous whole-body treatment for liver cancer.
• Be in good general health, with a performance status score of 0 or 1.
• Have a Child-Pugh Class A liver function score.

Exclusion Criteria

• Have moderate or severe fluid buildup in the abdomen (ascites).
• Have a history of brain-related liver disease (hepatic encephalopathy).
• Have active cancer spread to the brain or spinal cord.
• Have a high risk of bleeding or abnormal connections between organs (fistula).
• Have had another cancer within the last 3 years.
• Have had an organ or stem cell transplant.
• Have active autoimmune diseases needing treatment in the past 2 years.
• Have significant heart disease within the last 6 months.
• Have had major surgery or severe injury within 4 weeks before starting the study or plan to have major surgery during the study.
• Have a history of severe bleeding disorders or blood clotting issues.
• Have severe ulcers, unhealed wounds, or recent serious gastrointestinal issues.
• Have active or chronic infections.
• Have a history of immune system deficiencies.