Study on How Hormone Therapy Before Surgery Affects Breast Cancer Treatment Outcomes
Sponsor: Memorial Sloan Kettering Cancer Center
ClinicalTrials ID:NCT07483307
This study is examining whether hormone therapy given before surgery can improve surgical outcomes for patients with a specific type of breast cancer called invasive lobular carcinoma (ILC). The focus is on whether this treatment reduces the likelihood of cancer cells being found at the edges of the tissue removed during surgery.
Patient Parameters
| Parameter | Options |
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Program Overview
The aim of this study is to evaluate the effectiveness of hormone therapy given before surgery in patients with invasive lobular carcinoma (ILC) who are undergoing breast-conserving surgery. Researchers want to find out if this approach can lower the risk of having cancer cells at the margins of the tissue removed during surgery, which is known as positive margins.
Eligibility Criteria
Inclusion Criteria
- Must provide written informed consent to participate.
- Postmenopausal women aged 50 years or older.
- Diagnosed with invasive lobular carcinoma (ILC) and planning to have breast-conserving surgery.
- Tumors must be estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2-), meaning:
- ER+: At least 10% of tumor cells show estrogen receptor activity.
- HER2-: Little to no HER2 protein is present in the tumor cells.
Exclusion Criteria
- Previous breast cancer in the same breast.
- Advanced regional disease or stage 4 cancer.
- Patients who need chemotherapy before surgery, as determined by their doctor.
- Patients who cannot have breast surgery due to inoperable or stage 4 cancer.
- Allergy to gadolinium, which prevents the use of breast MRI.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) | 07920 | Basking Ridge | New Jersey |
| Memorial Sloan Kettering Monmouth (Limited Protocol Activities) | 07748 | Middletown | New Jersey |
| Memorial Sloan Kettering Bergen (Limited Protocol Activities) | 07645 | Montvale | New Jersey |
| Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) | 11725 | Commack | New York |
| Memorial Sloan Kettering Westchester (Limited Protocol Activities) | 10604 | Harrison | New York |
| Memorial Sloan Kettering Cancer Center (All Protocol Activities) | 10065 | New York | New York |
| Memorial Sloan Kettering Nassau (Limited Protocol Activities) | 11553 | Uniondale | New York |
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