Study on Standard Chemotherapy and Bevacizumab With or Without INCA33890 for First-Line Treatment of Metastatic Colorectal Cancer

Inclusion Criteria

• Have stage IV colorectal cancer that cannot be surgically removed.
• Have not received any prior systemic treatment for cancer that has spread or cannot be removed.
• May have had previous treatment if the cancer did not return within 12 months after finishing.
• Have cancer that can be measured using standard criteria.
• Be in good overall health with a performance status of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Have adequate organ function based on lab tests.

Exclusion Criteria

• Have a specific type of genetic instability in the cancer known as MSI-H/dMMR.
• Have a specific genetic mutation called BRAF V600E.
• Have untreated or worsening cancer that has spread to the brain or spinal cord.
• Have had another type of cancer within the past 2 years.
• Have been treated with certain immune therapies in the past 3 years.
• Have an active autoimmune disease that needed treatment in the past 2 years.
• Have any significant or uncontrolled medical conditions.
• Have had an organ transplant, including stem cell transplants.

Other specific criteria may apply.