Study on Nivolumab and Cabozantinib for Patients with Non-Clear Cell Kidney Cancer

Inclusion Criteria

• Must sign a consent form to participate.
• Have advanced kidney cancer that cannot be surgically removed.
• Have had 0 or 1 prior treatments for kidney cancer.
• Provide a tumor sample for diagnosis.
• Have measurable cancer as per standard criteria.
• Be 18 years or older.
• Have a performance status score of 70 or higher, indicating the ability to care for oneself.
• Have recovered from any side effects of previous treatments.
• Have adequate blood and organ function based on specific lab tests.
• Women of childbearing potential must agree to use effective birth control during the study and for a period after.
• Men must agree to use birth control during the study and for a period after.
• Must not be pregnant at the start of the study.
• Must understand and agree to follow the study requirements.

Exclusion Criteria

• Have had previous treatment with certain immunotherapy drugs or cabozantinib.
• Have received certain cancer treatments recently.
• Have cancer in the brain or spinal cord.
• Require ongoing pain medication that is not stable.
• Are taking high doses of steroids or other immune-suppressing drugs.
• Have uncontrolled fluid buildup in the body.
• Have high calcium levels that are not controlled.
• Have had another cancer within the last 2 years, except for certain skin cancers.
• Are pregnant or breastfeeding.
• Have severe allergies to similar drugs.
• Have HIV or active hepatitis B or C.
• Have significant heart disease or uncontrolled high blood pressure.
• Have had major surgery recently.
• Have had a stroke or significant vascular disease recently.
• Have bleeding disorders or significant bleeding history.
• Have gastrointestinal issues that require special feeding.
• Have a history of abdominal issues like fistulas or perforations.
• Have other serious health conditions that could affect participation.
• Cannot swallow pills.
• Have a history of not following medical advice.
• Are taking certain blood thinners that are not allowed in the study.
• Have significant bleeding or blood in urine or vomit recently.
• Have tumors affecting major blood vessels or the gastrointestinal tract.
• Have had recent radiation therapy that could affect participation.