Study on the Safety and Effectiveness of Lete-Cel in Patients with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Inclusion Criteria

• Must be 10 years or older and weigh at least 40 kg if receiving the treatment.
• Diagnosed with synovial sarcoma or myxoid/round cell liposarcoma, confirmed by specific lab tests.
• Cancer must be advanced, meaning it has spread or cannot be removed by surgery.
• Must have a life expectancy of at least 24 weeks.
• Must have specific genetic markers related to the cancer type.
• Must have previously received standard treatments for the cancer.
• Must test positive for certain HLA markers.
• Tumor must show a specific protein called NY-ESO-1.
• Must have good heart function and overall health.
• Must have adequate organ function and blood cell counts.
• Must be able to undergo a procedure to collect blood cells.
• Women of childbearing potential must have a negative pregnancy test.
• Must have measurable disease and evidence of disease progression.
• Must provide a tumor sample for analysis if possible.

Exclusion Criteria

• Cancer has spread to the brain or spinal cord.
• Have another cancer that is not in complete remission.
• Have received previous treatments targeting NY-ESO-1.
• Have had gene therapy or stem cell transplants.
• Have serious health conditions that could affect treatment.
• Have received certain cancer treatments or vaccines recently.
• Have had major surgery recently.