Study on Plinabulin and Pegfilgrastim for People with Multiple Myeloma Undergoing Stem Cell Transplant

Inclusion Criteria

• Diagnosed with multiple myeloma and undergoing a stem cell transplant with melphalan.
• Aged between 18 and 75 years.
• Have enough stem cells available for the transplant.
• Have a performance status score of 60 or higher, indicating the ability to carry out daily activities.
• Meet specific organ function requirements based on heart and lung tests.
• Meet certain blood test criteria, including platelet count and liver and kidney function.
• Women of childbearing potential must have a negative pregnancy test and agree to use effective birth control during and for 180 days after treatment.
• Men must agree to use birth control and not donate sperm for 180 days after treatment.

Exclusion Criteria

• Have had another cancer within the past 2 years, except for certain treated skin or cervical cancers.
• Have a significant infection, including HIV or hepatitis C, or active hepatitis B.
• Have uncontrolled infections despite treatment.
• Have taken an investigational drug or used an investigational device recently.
• Have been hospitalized for infection or major surgery recently.
• Are pregnant, breastfeeding, or planning to become pregnant or father a child during or shortly after the study.
• Have uncontrolled medical or psychological conditions that prevent following the study protocol.
• Have significant heart problems, such as a recent heart attack or uncontrolled high blood pressure.
• Have had a stroke or significant neurological issues recently.
• Have certain gastrointestinal disorders or allergies to specific substances.
• Have any medical conditions that pose excessive risk, as judged by the study doctor.
• Are unwilling or unable to follow the study procedures.