Study on Anti-Testosterone Medications and Radiation for High-Risk Prostate Cancer

Inclusion Criteria

• Confirmed diagnosis of prostate cancer.
• Must have at least one high-risk feature, such as a Gleason score of 8-10, PSA level of 20 or higher, or advanced clinical stage.
• Must be in good general health with a performance status score of 70% or higher.
• Must have normal liver and kidney function based on specific blood tests.
• Must have adequate blood cell counts and other lab values.
• Must be willing to provide informed consent and follow study procedures.
• Men aged 18 and older.
• Must agree to use effective contraception during the study and for three months after.
• Must not donate sperm during the study and for three months after.

Exclusion Criteria

• Evidence of cancer spread to other parts of the body.
• Previous treatment for prostate cancer, except for certain hormone therapies.
• Use of certain medications that affect hormone levels or the immune system within a specified time before the study.
• History of other cancers within the last three years, except for certain skin cancers or early-stage cancers in remission.
• Severe liver problems or other serious health conditions.
• Recent major surgery or presence of a pacemaker.
• Active infections or medical conditions that would make certain medications unsafe.
• History of heart problems, seizures, or other conditions that could increase risk during the study.
• Uncontrolled diabetes, heart disease, or high blood pressure.
• Gastrointestinal issues that could affect medication absorption.
• Participation in another drug study within four weeks of this study.