Study on a Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) for Children and Adults Preparing for a Bone Marrow Transplant

Inclusion Criteria

• Patients receiving their first bone marrow transplant for certain blood cancers, such as:
  • Acute myeloid leukemia (AML) with specific risk features or in certain stages of remission.
  • Acute leukemias of ambiguous lineage in certain stages of remission.
  • Acute lymphoid leukemia (ALL) with high risk of relapse or in certain stages of remission.
  • Myelodysplastic syndromes (MDS) with specific risk factors or genetic changes.
• Must be able to handle the treatment to reduce cancer cells.
• Age requirements:
  • Regimen A: 4 to 60 years old
  • Regimen B: No age limit
• Must have good organ function, including:
  • Liver: Specific limits on bilirubin and liver enzymes.
  • Kidneys: Specific limits on creatinine and kidney function tests.
• Must have normal heart and lung function.
• Must be in good overall health, with specific performance status scores.
• Must be willing to participate and sign a consent form.

Exclusion Criteria

• Patients with active cancer outside the bone marrow.
• Patients with active cancer in the central nervous system.
• Uncontrolled infections at the time of transplant.
• Previous bone marrow transplant recipients.
• Patients who test positive for HIV or HTLV.
• Pregnant or breastfeeding women.
• Patients not willing to use birth control during the study.
• Patients or guardians unable to give consent or follow the study protocol.

Donor Inclusion Criteria:

• Related or unrelated donors who are a perfect match based on specific genetic markers.
• Must be able to give consent for the donation process.
• Must meet standard criteria for donating stem cells.