Study on Orca-T for Patients Undergoing Stem Cell Transplant for Blood Cancers

Inclusion Criteria

• Must have a donor who is a perfect match for specific genetic markers.
• Diagnosed with certain blood cancers, such as acute leukemia or myelodysplastic syndromes, and in remission or with minimal disease.
• Planned to receive a specific type of high-dose chemotherapy before the transplant.
• Heart function must be adequate, with specific measurements.
• Lung function must be adequate, with specific measurements.
• Women of childbearing potential must have a negative pregnancy test.
• Liver function tests must be within normal limits.
• Must test negative for COVID-19.
• Must have a certain level of kidney function.
• Must have an intermediate or high risk of disease progression.

Exclusion Criteria

• Have had a previous stem cell transplant.
• Currently taking certain medications that suppress the immune system, except for low-dose steroids.
• Planned to receive additional donor cells or treatments that remove T-cells.
• Have antibodies against the donor's cells.
• Have a low performance score indicating poor health.
• Have a high score on a specific index measuring other health conditions.
• Have uncontrolled infections at the time of enrollment.
• Test positive for certain viruses, including HIV and hepatitis.
• Have allergies to specific medications or proteins.
• Have uncontrolled autoimmune diseases requiring treatment.
• Have other active cancers or diseases within the past year, except for certain skin cancers.
• Have social or psychological issues that prevent participation in the study.
• Women who are pregnant or breastfeeding.
• Women and men who are not willing to use birth control or abstain from sex for one year after the transplant.