Study of IMNN-001 with Chemotherapy for Treating Ovarian Cancer (OVATION 2)

Inclusion Criteria

• Have a suspected diagnosis of certain types of ovarian, fallopian tube, or primary peritoneal cancer confirmed by a biopsy.
• Have advanced cancer classified as stage III or IV according to the International Federation of Gynecology and Obstetrics (FIGO).
• Have specific types of cancer cells, such as high-grade serous adenocarcinoma or endometrioid adenocarcinoma.
• Have adequate bone marrow, kidney, liver, and nerve function as determined by specific medical tests.
• Be free of active infections or serious uncontrolled medical conditions within four weeks before starting the study.
• Stop any hormonal therapy for the cancer at least one week before the first treatment, but hormone replacement therapy is allowed.
• Have a performance status score of 0, 1, or 2, indicating the ability to carry out daily activities with some limitations.
• Women of childbearing potential must have a negative pregnancy test and use effective contraception. Breastfeeding must be stopped before joining the study.
• Have satisfactory results from initial lab tests and diagnostic procedures.
• Sign an informed consent form and agree to the release of personal health information.
• Be at least 18 years old.

Exclusion Criteria

• Have previously received the IMNN-001 treatment.
• Have allergies to similar compounds or other study drugs.
• Have used corticosteroids or need ongoing immunosuppressive therapy within two weeks before the study.
• Have active autoimmune diseases requiring treatment, such as lupus or rheumatoid arthritis.
• Have had other invasive cancers within the last three years, except for certain skin cancers.
• Have had radiation therapy to the abdomen or pelvis, unless it was for specific cancers and completed over three years ago.
• Have had chemotherapy for abdominal or pelvic tumors, unless it was for breast cancer and completed over three years ago.
• Have active hepatitis.
• Have severe medical problems unrelated to cancer that would interfere with the study.
• Are pregnant, breastfeeding, or not using adequate contraception.
• Have brain-related conditions, such as uncontrolled seizures or recent strokes.
• Have conditions that would interfere with the placement of the catheter needed for the study treatment, such as recent abdominal surgery or intestinal issues.