Study on Surgery, Chemotherapy, and Targeted Radiation for Locally Advanced Malignant Pleural Mesothelioma

Inclusion Criteria

• Agree to participate by signing a consent form.
• Diagnosed with stage I-III malignant pleural mesothelioma, confirmed by a medical center.
• Cancer type must be epithelioid or biphasic, with less than 10% sarcomatoid cells.
• No signs of cancer spreading to other parts of the body.
• Aged between 18 and 80 years.
• Good overall health with a performance status of 80% or higher.
• Lung function tests must show adequate breathing capacity.
• If there are concerns about kidney function, a special kidney scan may be done before radiation.
• Must have adequate blood cell counts and liver function before starting chemotherapy.

Exclusion Criteria

• Cancer type with more than 10% sarcomatoid cells.
• Need for continuous oxygen therapy.
• Previous removal of a kidney on the opposite side of the cancer.
• Previous treatments inside the chest cavity, except for pleurodesis.
• Previous chest radiation that prevents new radiation treatment.
• Large tumors in the lung fissure that prevent safe radiation.
• Undergoing a more extensive lung surgery called extrapleural pneumonectomy.
• Active infections requiring treatment.
• Another active cancer, except for certain skin cancers.
• Serious, unstable medical conditions.
• Fluid buildup that cannot be controlled by drainage.
• Significant fluid around the lungs before or during chemotherapy.
• Heart failure that is not controlled.
• Pregnant or breastfeeding women.
• Men and women not using effective birth control.

Reproductive risks: Participants should avoid pregnancy or fathering a child during the study, as the drugs used can harm an unborn baby. Women should not breastfeed while participating. Women of childbearing age will be advised to use birth control.