Study on Improving Haplo-Cord Transplant Outcomes by Targeting Specific Antigens

Program Overview

This study aims to improve the results of haplo-cord transplants, which involve using stem cells from both umbilical cord blood and a family member. The goal is to find a better match between the donor and recipient by focusing on specific antigens, rather than just the number of cells. Participants will receive chemotherapy before the transplant, and no experimental drugs are used. The study hopes to show that this matching method can lead to better recovery and fewer complications.

Description

This clinical trial is for patients with blood cancers or disorders who need a stem cell transplant but do not have a fully matched donor. Typically, stem cells from umbilical cord blood are used, but they can take a long time to grow and may lead to extended hospital stays. This study uses a new method called haplo-cord transplantation, which combines stem cells from a family member and umbilical cord blood. The aim is to speed up recovery and reduce the need for transfusions. Over time, the family member's cells are replaced by the cord blood cells. The study will focus on matching specific antigens to improve outcomes, rather than just the number of cells. This approach has shown promising results in previous cases.

Eligibility Criteria

Locations