Study on Post-Surgery Chemotherapy Treatments for Appendix, Colon, or Rectum Cancer with Peritoneal Spread

Inclusion Criteria

• Must be 18 years or older.
• Diagnosed with cancer of the appendix or colon/rectum that has spread to the abdominal lining.
• Planning to have surgery to remove all visible cancer in the abdomen.
• In good general health, able to perform daily activities with minimal restrictions.
• Have adequate blood cell counts and organ function based on specific medical tests.
• Women of childbearing age must test negative for pregnancy and agree to use effective birth control during the study.
• Men must agree to use reliable birth control methods during the study.
• Must provide written consent to participate in the study.
• If previously diagnosed with endometrial cancer, must have had a low-stage, non-aggressive form.

Exclusion Criteria

• Have had chemotherapy directly into the abdomen before.
• Have certain types of tumors with low potential to spread.
• Have had other cancers unless they were treated and inactive for over three years.
• Cancer has spread beyond the abdomen or lymph nodes.
• Pregnant or breastfeeding women.
• Have medical conditions that prevent understanding or participating in the study.
• Have active heart disease or uncontrolled high blood pressure.
• Have severe lung disease or heart failure.
• Have had a stroke or other severe medical issues that limit participation.
• Allergic to specific chemotherapy drugs used in the study.
• Have extensive scar tissue in the abdomen that prevents treatment.
• Taking medications that cannot be safely stopped for the study.
• Have a life expectancy of less than 12 weeks.