Study on PF-08634404 with Chemotherapy for Adults with Advanced or Metastatic Non-Small Cell Lung Cancer

Inclusion Criteria

• Be 18 years or older.
• Have a confirmed diagnosis of locally advanced or metastatic non-small cell lung cancer (NSCLC) that cannot be completely removed by surgery or cured with chemoradiotherapy.
• Have available tumor tissue samples for testing.
• Have PD-L1 status results from local testing.
• Have measurable disease based on specific criteria.
• Have a performance status score of 0 or 1, indicating full activity or some restriction in strenuous activities.
• Have an expected survival of at least 12 weeks.

Exclusion Criteria

• Have known genetic changes in the cancer that have available first-line treatments.
• Have active brain lesions, unless they have been treated and are stable.
• Have a significant risk of bleeding or fistula.
• Have had another cancer within the past 3 years, unless it was treated and there is no residual disease.
• Have unresolved side effects from previous cancer treatments.
• Have a history of severe allergies to study medications.
• Have had an organ or stem cell transplant.
• Have certain lung conditions or severe respiratory diseases.
• Have uncontrolled health conditions like heart disease or diabetes.
• Have had major surgery recently.
• Have a history of severe bleeding disorders or gastrointestinal issues.
• Have active infections like HIV, hepatitis B, or hepatitis C.
• Have a history of immune system deficiencies.
• Have medical or psychiatric conditions that increase the risk of participation.
• Have had previous treatments for advanced NSCLC, including certain immunotherapies or radiotherapy.
• Are currently taking certain medications or treatments that are not allowed during the study.
• Are pregnant, breastfeeding, or not willing to use contraception if of childbearing potential.