Study on Ramucirumab or Merestinib for Advanced or Metastatic Biliary Tract Cancer

Inclusion Criteria

• Must be in good general health with an activity level that allows for light work or better.
• Must have a confirmed diagnosis of biliary tract cancer that cannot be removed by surgery, has come back, or has spread to other parts of the body.
• Must have cancer that can be measured by standard medical tests.
• Must have proper bile drainage and good organ function.
• Must be sterile, postmenopausal, or agree to use effective birth control.
• Women who can have children must test negative for pregnancy before starting the study.
• Must agree to provide blood and tumor samples for research purposes.

Exclusion Criteria

• Cannot have had previous treatment for advanced or metastatic cancer.
• Cannot have a history of severe liver problems or fluid buildup in the abdomen.
• Cannot have had recent severe kidney problems.
• Cannot have had major surgery or serious injury recently.
• Cannot plan to have major surgery during the study.
• Cannot have cancer that has spread to the brain or spinal cord.
• Cannot have had recent serious heart or blood vessel problems.
• Cannot have uncontrolled high blood pressure.
• Cannot have had another cancer within the last 5 years.
• Cannot have had recent serious digestive system problems.
• Cannot be allergic to any study medications.
• Cannot have certain blood clotting disorders.
• Cannot have uncontrolled health conditions that pose a high risk.
• Cannot have mixed types of liver and bile duct cancer.
• Cannot have certain heart rhythm problems.