Study Comparing Two Types of Radiation Therapy for Patients with Brain Cancer Spread from Other Parts of the Body

Program Overview

This study is investigating two different radiation treatments for patients who have had brain cancer spread from other parts of the body and have undergone surgery to remove it. The trial compares single fraction stereotactic radiosurgery (a one-time high-dose radiation) with fractionated stereotactic radiosurgery (multiple smaller doses over time) to see which is more effective in preventing cancer from returning and improving patients' quality of life.

Description

The main goal of this study is to find out if giving multiple smaller doses of radiation (fractionated stereotactic radiosurgery or FSRS) is better at preventing cancer from coming back in the area where it was removed compared to a single high-dose treatment (single-fraction stereotactic radiosurgery or SSRS).

Other goals include:

• Checking if patients feel better emotionally and have a better quality of life with FSRS compared to SSRS.
• Seeing if patients live longer with FSRS.
• Comparing how independent patients are after each treatment.
• Looking at side effects and how they might be affected by other treatments like immunotherapy.
• Checking for differences in radiation-related brain damage and cancer spread patterns.
• Evaluating if FSRS delays the need for whole-brain radiation therapy.
• Assessing long-term survivors for emotional well-being and quality of life.
• Exploring differences in cognitive function and quality of life with FSRS.

Participants will be randomly assigned to one of two groups: one receiving SSRS in one session, and the other receiving FSRS over three or five sessions. Follow-up visits will occur at various intervals up to five years after treatment.

Eligibility Criteria

Locations