Testing Lenvatinib in Patients with Adenoid Cystic Carcinoma

Inclusion Criteria

• Must have a confirmed diagnosis of adenoid cystic carcinoma, including cancers from non-salivary gland sites.
• Cancer must have returned or spread and cannot be treated with surgery or radiotherapy.
• At least 2 weeks must have passed since the last cancer treatment, with recovery from any side effects.
• Must have measurable cancer that can be tracked by scans.
• Must have a new or worsening cancer lesion or symptoms within 6 months before joining the study.
• Must provide a sample of the tumor tissue for study purposes.
• Must be 18 years or older.
• Must be in good general health with a performance status score of less than 2.
• Must have adequate blood, liver, and kidney function based on specific tests.
• Must be able to understand and sign a consent form.
• Women of childbearing potential must have a negative pregnancy test before starting the study.
• Must agree to use effective birth control during the study and for 3 months after the last dose.
• Must be able to swallow pills.

Exclusion Criteria

• Cannot be receiving other cancer treatments besides the study drug.
• Cannot have used lenvatinib before.
• Cannot have uncontrolled high blood pressure.
• Cannot be using another experimental drug or device.
• Cannot have significant protein in the urine.
• Cannot have serious heart problems or recent heart attacks.
• Cannot have had recent blood clots or strokes.
• Cannot have untreated or symptomatic brain tumors.
• Cannot have had major surgery or injury recently.
• Cannot have bleeding disorders or recent severe bleeding.
• Cannot be on unstable blood thinners.
• Cannot have active infections like HIV or hepatitis.
• Cannot have a non-healing wound or ulcer.
• Cannot have kidney failure requiring dialysis.
• Cannot have a seizure disorder needing medication.
• Cannot have lung disease with symptoms.
• Cannot have had an organ transplant.
• Cannot have conditions affecting absorption of medication.
• Cannot be pregnant or breastfeeding.
• Cannot have any condition that makes participation unsafe.