Study on Using Stereotactic Body Radiation Therapy (SBRT) for Patients with Metastatic Breast and Lung Cancers

Inclusion Criteria

• Must be 18 years or older.
• Able to understand and agree to participate in the study.
• Have metastatic breast or lung cancer confirmed by imaging and lab tests.
• For breast cancer: Must have triple negative breast cancer or other high-risk breast cancer that has progressed despite treatment.
• For lung cancer: Must have non-small cell lung cancer (NSCLC) without certain genetic mutations, or with specific mutations that have progressed after targeted therapy.
• Must have received at least one prior treatment for cancer.
• Previous immunotherapy or radiation therapy is allowed.
• Can have more than 5 metastases, but only 1-5 can be actively growing.
• Must have certain medical conditions that prevent participation in other drug trials, such as active liver disease or a history of autoimmune disease.
• Must have measurable disease progression in up to 5 lesions, as defined by specific medical criteria.
• All growing tumor sites must be treatable with radiation.
• No limit on the total number of metastases.
• Brain metastases can be treated before joining the study.
• Any urgent symptoms requiring radiation can be treated before joining the study.

Exclusion Criteria

• Cannot be pregnant.
• Cannot have leptomeningeal disease (cancer spread to the membranes around the brain and spinal cord).
• Cannot have serious medical conditions that prevent radiation therapy, like certain genetic disorders.
• Any other condition that the study doctor believes makes participation inappropriate.