Study on Atezolizumab and Bevacizumab Versus Monitoring for Preventing Return of Liver Cancer After Surgery or Ablation

Inclusion Criteria

• First-time diagnosis of liver cancer that has been completely removed by surgery or treated with ablation (a procedure using heat to destroy cancer cells) within 4-12 weeks before joining the study.
• No major cancer spread to blood vessels or other parts of the body, confirmed by scans.
• Fully recovered from surgery or ablation at least 4 weeks before joining the study.
• High risk of cancer returning after treatment.
• If post-surgery chemoembolization was done, full recovery at least 4 weeks before joining.
• Available tumor tissue sample from surgery.
• Good overall health with a performance status of 0 or 1.
• Good liver function (Child-Pugh Class A).
• Adequate blood and organ function.
• Women who can have children must agree to use birth control or abstain from sex.
• Men must agree to use condoms or abstain from sex and not donate sperm.

Exclusion Criteria

• Specific types of liver cancer like fibrolamellar, sarcomatoid, or mixed types.
• Evidence of cancer remaining, returning, or spreading at the time of joining the study.
• Significant fluid buildup in the abdomen (ascites).
• History of brain-related liver disease (hepatic encephalopathy).
• Recent bleeding from untreated esophageal or stomach veins.
• More than one cycle of post-surgery chemoembolization.
• Active or past autoimmune diseases or immune deficiencies.
• Lung diseases like pulmonary fibrosis or pneumonia.
• Recent serious heart problems or unstable heart conditions.
• Other cancers within the last 5 years, except for low-risk types.
• Active tuberculosis.
• Any condition that makes the study drugs unsafe or complicates treatment.
• Pregnant or breastfeeding women, or those planning to become pregnant during or shortly after the study.
• Co-infection with hepatitis B and C or hepatitis D.
• Uncontrolled high calcium levels in the blood.
• Previous treatment for liver cancer before surgery or ablation.
• Use of immune system-affecting drugs.
• Uncontrolled high blood pressure.
• History of severe high blood pressure events.
• Significant blood vessel diseases.
• Bleeding disorders or blood clotting issues.
• Recent use of blood thinners or aspirin.
• Recent major surgery or non-healing wounds.
• Daily use of certain anti-inflammatory drugs.