Study on Preserving Organs in Patients with Early Rectal Cancer
Sponsor: Fox Chase Cancer Center
ClinicalTrials ID:NCT03548961
This clinical trial is exploring a treatment plan for early-stage rectal cancer that aims to preserve the rectum by using chemotherapy, followed by a minor surgery and additional treatment. The study will assess how well this approach works in avoiding more extensive surgery.
Patient Parameters
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Program Overview
The study is testing a treatment plan for patients with early-stage rectal cancer. It involves giving chemotherapy first, then performing a small surgery to remove the tumor, followed by additional chemotherapy and radiation. The goal is to see if this approach can effectively treat the cancer while preserving the rectum. Patients will undergo various tests before starting treatment, and their response to the initial chemotherapy will determine the next steps. Those who respond well will have the tumor surgically removed and receive further treatment. Patients will be closely monitored for several years to track their progress.
Eligibility Criteria
Exclusion Criteria
- Patients who cannot safely receive the chemotherapy and radiation used in this study.
- Patients with very small, low-risk tumors that meet specific criteria.
- Patients with larger, high-risk tumors that meet certain conditions.
- Patients with advanced rectal cancer or cancer that has spread to lymph nodes.
- Patients currently taking other experimental treatments.
- Patients who have had chemotherapy for other cancers in the past three years.
- Patients who have received radiation therapy to the pelvic area before.
- Patients with other cancers that required treatment in the last three years.
- Patients with known allergies to the study drugs.
- Patients with serious health issues like heart problems or infections that could interfere with the study.
- Patients with HIV who are on certain medications.
- Pregnant or breastfeeding women.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Fox Chase Cancer Center | 19111 | Philadelphia | Pennsylvania |
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