Study on Short Course Radiation Therapy Combined with Chemotherapy for Early Stage Gastric Cancer

Inclusion Criteria

• Newly diagnosed with gastric adenocarcinoma, a type of stomach cancer. Tumors that extend to the gastroesophageal junction are allowed.
• Cancer stage must be determined by specific medical imaging tests.
• Must be medically fit to receive standard chemotherapy.
• Aged 18 years or older.
• In good general health, with an ECOG performance status of 0 to 2.
• Have adequate blood cell counts and organ function, including:
  • Neutrophil count of at least 1.5 K/cumm.
  • Platelet count of at least 100 K/cumm.
  • Kidney function with creatinine clearance over 50 mL/min.
• Women and men must agree to use effective birth control during the study and for a period after the study ends.
• Must be able to understand and sign a consent form, or have a representative do so on their behalf.

Exclusion Criteria

• Have had previous surgery, radiation, or chemotherapy for stomach or esophageal cancer.
• Have had surgery on the esophagus or stomach.
• Have a specific type of tumor at the gastroesophageal junction (Siewert I-II).
• Have another cancer that could interfere with the study treatment.
• Are currently taking other experimental drugs.
• Have a history of severe allergic reactions to similar chemotherapy drugs.
• Have uncontrolled health issues like active infections, heart failure, or significant heart problems.
• Are pregnant or breastfeeding. Women must have a negative pregnancy test before joining the study.
• Have HIV and are not on effective treatment with an undetectable viral load for at least 6 months. Those on effective treatment with a stable viral load are eligible.