Study Comparing BMS-986504 with Nab-paclitaxel and Gemcitabine Versus Placebo for Untreated Metastatic Pancreatic Cancer with MTAP Deletion

Sponsor: Bristol-Myers Squibb

Sponsor score: 60

ClinicalTrials ID:NCT07076121

This clinical trial is testing a new drug, BMS-986504, combined with standard chemotherapy drugs Nab-paclitaxel and Gemcitabine, against a placebo with the same chemotherapy in patients with untreated metastatic pancreatic cancer that has a specific genetic deletion.

Patient Parameters

Program Overview

The goal of this study is to evaluate the safety and effectiveness of a new drug, BMS-986504, when used with chemotherapy drugs Nab-paclitaxel and Gemcitabine, compared to a placebo with the same chemotherapy. This study is for patients with metastatic pancreatic ductal adenocarcinoma (PDAC) who have not received prior treatment for their cancer and have a specific genetic deletion called MTAP.

Eligibility Criteria

Inclusion Criteria

  • Have a confirmed diagnosis of metastatic pancreatic ductal adenocarcinoma (PDAC).
  • Have a specific genetic deletion called MTAP in the tumor.
  • Have cancer that has spread and can be measured by scans.
  • Have not received any previous treatments for cancer that has spread.
  • May have received one cycle of Nab-paclitaxel and Gemcitabine if needed, as long as the cancer has not worsened and the treatment was tolerated.
  • The initial cycle of Nab-paclitaxel and Gemcitabine must be completed before joining the study.

Exclusion Criteria

  • Have another active cancer that needs treatment or had another cancer within the last two years.
  • Other specific criteria as defined by the study protocol.

Locations

FACILITYZIPCITYSTATE
Local Institution - 014285054PhoenixArizona
Local Institution - 036585724TucsonArizona
Highlands Oncology Group72762SpringdaleArkansas
Local Institution - 037392037La JollaCalifornia
Local Institution - 015794115San FranciscoCalifornia
Local Institution - 013932224JacksonvilleFlorida
Local Institution - 013233612TampaFlorida
Local Institution - 036730322AtlantaGeorgia
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital30060MariettaGeorgia
Local Institution - 012683712BoiseIdaho

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