Study Comparing BMS-986504 with Nab-paclitaxel and Gemcitabine Versus Placebo for Untreated Metastatic Pancreatic Cancer with MTAP Deletion
Sponsor: Bristol-Myers Squibb
ClinicalTrials ID:NCT07076121
This clinical trial is testing a new drug, BMS-986504, combined with standard chemotherapy drugs Nab-paclitaxel and Gemcitabine, against a placebo with the same chemotherapy in patients with untreated metastatic pancreatic cancer that has a specific genetic deletion.
Patient Parameters
| Parameter | Options |
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Program Overview
The goal of this study is to evaluate the safety and effectiveness of a new drug, BMS-986504, when used with chemotherapy drugs Nab-paclitaxel and Gemcitabine, compared to a placebo with the same chemotherapy. This study is for patients with metastatic pancreatic ductal adenocarcinoma (PDAC) who have not received prior treatment for their cancer and have a specific genetic deletion called MTAP.
Eligibility Criteria
Inclusion Criteria
- Have a confirmed diagnosis of metastatic pancreatic ductal adenocarcinoma (PDAC).
- Have a specific genetic deletion called MTAP in the tumor.
- Have cancer that has spread and can be measured by scans.
- Have not received any previous treatments for cancer that has spread.
- May have received one cycle of Nab-paclitaxel and Gemcitabine if needed, as long as the cancer has not worsened and the treatment was tolerated.
- The initial cycle of Nab-paclitaxel and Gemcitabine must be completed before joining the study.
Exclusion Criteria
- Have another active cancer that needs treatment or had another cancer within the last two years.
- Other specific criteria as defined by the study protocol.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Local Institution - 0142 | 85054 | Phoenix | Arizona |
| Local Institution - 0365 | 85724 | Tucson | Arizona |
| Highlands Oncology Group | 72762 | Springdale | Arkansas |
| Local Institution - 0373 | 92037 | La Jolla | California |
| Local Institution - 0157 | 94115 | San Francisco | California |
| Local Institution - 0139 | 32224 | Jacksonville | Florida |
| Local Institution - 0132 | 33612 | Tampa | Florida |
| Local Institution - 0367 | 30322 | Atlanta | Georgia |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | 30060 | Marietta | Georgia |
| Local Institution - 0126 | 83712 | Boise | Idaho |
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