Study on AZD4512 Alone or with Other Cancer Drugs for Treating Relapsed or Hard-to-Treat B-cell Non-Hodgkin Lymphoma

Inclusion Criteria

• Must be 18 years or older.
• Have a confirmed diagnosis of B-cell Non-Hodgkin Lymphoma (B-NHL) according to the World Health Organization (WHO) 2021 classification.
• In the initial phase, any B-NHL subtype is allowed, except for some specific types. In later phases, only certain subtypes like large B-cell lymphomas, mantle cell lymphoma, and follicular lymphoma grades 1-3a are included.
• Must have B-NHL that has returned or is not responding after at least two previous treatments and have no other standard treatment options that improve survival.
• Must have measurable disease according to specific medical criteria.
• Must be in relatively good health with an ECOG performance status of 2 or less.
• Must have adequate organ and bone marrow function as determined by specific medical tests.

Exclusion Criteria

• Cannot have certain types of B-NHL, such as post-transplant lymphoproliferative disease, Richter's transformation, Burkitt's lymphoma, or chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL).
• Cannot have active involvement of the central nervous system (CNS) by B-NHL.
• Cannot have received certain therapies like CAR-T or T cell engager therapies within 90 days before starting the study.
• Cannot have received any investigational drug or other systemic cancer therapies (except low-dose corticosteroids) within 21 days or 5 half-lives before starting the study.
• Cannot have had major surgery within 28 days before starting the study.
• Cannot be using certain medications that affect the heart or liver at the start of the study.
• Cannot have had other cancers within the last two years, except for certain non-threatening types.
• Cannot have unresolved side effects from previous treatments, serious uncontrolled medical conditions, or active infections within 14 days before starting the study.
• Cannot have a history or suspicion of significant lung disease.
• Women who are pregnant or breastfeeding are not eligible.