Study on MK-5684 for Treating Certain Solid Tumors

Inclusion Criteria

• For Breast Cancer Patients:
  • Have hormone receptor positive/HER2 negative breast cancer that cannot be surgically removed or has spread.
  • Have had the cancer worsen after at least one hormone-based treatment for metastatic cancer.
• For Ovarian Cancer Patients:
  • Have high-grade ovarian, fallopian tube, or primary peritoneal cancer.
  • Have received 4 to 8 cycles of platinum-based chemotherapy in the third-line setting.
• For Endometrial Cancer Patients:
  • Have advanced or recurrent low-grade endometrioid cancer.
  • Have not been treated or have had up to one prior platinum-based treatment.
• For All Participants:
  • Must have recovered from side effects of previous cancer treatments.
  • HIV-positive participants must have well-controlled HIV.
  • Hepatitis B positive participants must have undetectable viral load after antiviral therapy.
  • Hepatitis C positive participants must have undetectable viral load.

Exclusion Criteria

• For Breast Cancer Patients:
  • Cancer that can be treated with surgery or other curative treatments.
  • Cancer that has spread to vital organs and is causing severe symptoms.
• For Ovarian Cancer Patients:
  • Have certain types of ovarian cancer that are not eligible.
  • Have ovarian cancer that is resistant or unresponsive to platinum-based treatments.
  • Are candidates for surgery or radiotherapy aimed at curing the cancer.
• For Endometrial Cancer Patients:
  • Have high-grade endometrioid cancer or other specific types of cancer.
  • Are candidates for surgery or radiotherapy aimed at curing the cancer.
• For All Participants:
  • Have adrenal gland metastases.
  • Have difficulty swallowing or absorbing oral medications.
  • Have a history of adrenal insufficiency.
  • HIV-positive participants with certain conditions like Kaposi's sarcoma.
  • Have received a live vaccine within 30 days before starting the study.
  • Have another active cancer needing treatment in the past 3 years.
  • Have active brain metastases or cancer in the brain lining.
  • Have had a stem cell or organ transplant.
  • Have not fully recovered from major surgery.