Study on Image-Guided, Tumor-Focused Radiotherapy for Intermediate and High-Risk Prostate Cancer
Sponsor: University of California, San Diego
ClinicalTrials ID:NCT06990542
This clinical trial is testing a new type of radiotherapy that targets the tumor more precisely in patients with intermediate or high-risk prostate cancer. The goal is to see if this approach can reduce side effects compared to standard treatment.
Patient Parameters
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Program Overview
The study aims to find out if a new radiotherapy method that focuses directly on the tumor can lower the radiation dose to nearby organs, like the bladder and rectum, in patients with intermediate or high-risk prostate cancer. This could potentially reduce side effects and improve quality of life. Researchers will compare this new method to the standard whole-prostate treatment and will measure side effects, survival rates, and quality of life. They will also look at biomarkers that might predict who could experience more side effects from radiation therapy.
Description
This study is exploring a new way to treat prostate cancer using radiotherapy that targets the tumor more precisely. Traditional radiotherapy can cause long-term side effects, especially to the urinary and digestive systems, affecting patients' quality of life. By focusing the radiation more directly on the tumor, this new method aims to reduce these side effects while still effectively treating the cancer. Advanced imaging technologies help identify the tumor, allowing doctors to deliver higher doses of radiation to the cancerous area and lower doses to the rest of the prostate and nearby organs. This approach could lead to fewer side effects and better quality of life for patients. The study will compare this new method to the standard treatment to see which is more effective and has fewer side effects.
Eligibility Criteria
Inclusion Criteria
- Must provide signed and dated consent to participate
- Willingness to follow all study procedures and be available for the study duration
- Must be at least 18 years old
- Confirmed diagnosis of prostate cancer with plans for curative radiation therapy
- Tumor visible on prostate imaging scans, confirmed by biopsy
- If able to father a child, must use effective contraception during and for 6 months after treatment
Exclusion Criteria
- Have bilateral hip implants
- Have had prostate surgery
- Have had previous prostate cancer treatment, except for hormone therapy started within 90 days before joining the study, with compatible imaging done within 4 months before starting hormone therapy
- Have had radiation therapy to the area needing treatment in this study
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| University of California, San Diego | 92093 | La Jolla | California |
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