Study on Reduced Radiation and Chemotherapy for HPV-Positive Throat Cancer

Inclusion Criteria

• Diagnosed with HPV-positive squamous cell carcinoma of the throat (including tonsils, base of tongue, or throat walls) confirmed by biopsy.
• Cancer must be visible on scans or physically measurable at the primary site or lymph nodes.
• No evidence of cancer spread to distant parts of the body.
• Must have a CT or MRI scan of the neck.
• General health status should be good, with a performance score of 0-2 or a KPS score of 70 or higher.
• Must be 18 years or older.
• Adequate blood cell counts and organ function based on recent tests.
• Women of childbearing potential must have a negative pregnancy test before joining the study.
• Must be able to undergo MRI scans unless medically exempted.
• Must provide informed consent to participate in the study.

Exclusion Criteria

• Previous radiation therapy to the head and neck area.
• Having another primary cancer outside the throat unless approved by the study investigators.
• History of another invasive cancer unless disease-free for 3 years or with a high cure rate.
• Previous chemotherapy for the throat cancer being studied (chemotherapy for other cancers is allowed).
• Severe health conditions such as recent heart problems, active infections requiring IV antibiotics, or severe lung disease requiring hospitalization.