Study on AZD4360 for Adults with Advanced Solid Tumors

Inclusion Criteria

• Must be 18 years or older.
• Must be in good general health with a performance status of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Must have a life expectancy of at least 12 weeks.
• Must have adequate organ and bone marrow function.
• Must use contraception as required by local regulations.
• Must have a confirmed diagnosis of advanced or metastatic pancreatic, gastric, gastroesophageal junction, or biliary tract cancer with positive CLDN18.2 expression.
• Must have received at least one prior treatment for advanced or metastatic cancer.
• Must have at least one tumor that can be measured by scans.

Exclusion Criteria

• Cannot have HER2 positive gastric or gastroesophageal junction cancer.
• Cannot have active or unstable peptic ulcers or significant digestive tract bleeding.
• Cannot have significant fluid buildup in the abdomen that needs drainage.
• Cannot have cancer that has spread to the brain or other central nervous system issues.
• Cannot have spinal cord compression or be at high risk of paralysis.
• Cannot have a history of lung diseases like pneumonitis.
• Cannot have serious heart problems.
• Cannot have had another primary cancer within the last 2 years.
• Cannot have active hepatitis B or C.
• Cannot have uncontrolled HIV infection.
• Cannot have active tuberculosis.