Study on PET/CT Imaging for Small Cell Lung Cancer Using 89Zr-DFO-SC16.56

Inclusion Criteria

• Must be 18 years or older.
• Have a confirmed diagnosis of small cell lung cancer (SCLC), a neuroendocrine tumor, or prostate cancer with suspected neuroendocrine prostate cancer (NEPC).
• Have at least one tumor that is 2 cm or larger on a CT or MRI scan.
• For prostate cancer patients with only bone metastases, a recent PET scan, MRI, or bone scan showing new bone metastases is required.
• Be in good overall health with an ECOG performance status of 0 to 2, meaning fully active or restricted in physically strenuous activity but ambulatory.
• Women of childbearing potential must have a negative pregnancy test within two weeks before receiving the imaging agent.
• Have adequate organ function, including:
  • Neutrophil count of at least 1,500/mm³.
  • Hemoglobin level of at least 8.0 g/dL.
  • Platelet count of at least 75,000/mm³.
  • Bilirubin level within 1.5 times the normal limit.
  • AST and ALT levels within specified limits, depending on liver metastases.
  • Creatinine level within 1.5 times the normal limit.
• Provide a previous tumor biopsy sample for analysis, or be willing to undergo a PET/CT guided biopsy if necessary.

Exclusion Criteria

• Have a history of severe allergic reactions to human antibodies.
• Are pregnant or breastfeeding.
• Have a psychiatric condition that would prevent following study procedures.
• Cannot undergo a PET scan due to weight restrictions.