Study on E7386 Combined with Other Cancer Drugs for Patients with Solid Tumors

Inclusion Criteria

• For liver cancer (HCC) patients: Must have a confirmed diagnosis of liver cancer that cannot be removed by surgery.
• For other solid tumors: Must have a confirmed diagnosis of a solid tumor with no other effective treatment options.
• Must have a life expectancy of at least 12 weeks.
• Must be in good general health, with an ECOG performance status of 0 or 1.
• Must have recovered from any side effects of previous cancer treatments.
• Must have normal blood pressure, kidney, liver, and bone marrow function.
• Must have at least one measurable tumor that can be tracked using scans.
• For liver cancer patients: Must have a Child-Pugh score of A.
• For liver cancer patients: Must be at stage B or C according to the BCLC staging system.
• For endometrial cancer patients: Must have cancer that has progressed after previous treatments, including platinum-based chemotherapy and anti-PD-1 therapy.

Exclusion Criteria

• Have certain heart conditions, such as heart failure or abnormal heart rhythms.
• Have had major surgery within the last 21 days or minor surgery within the last 7 days.
• Are HIV positive.
• Have significant protein in the urine.
• Have an active infection requiring treatment.
• Have cancer that has spread to the brain unless it has been treated and is stable.
• Have certain bone diseases or conditions.
• Have had another type of cancer within the last 24 months.
• For liver cancer patients: Have had issues with lenvatinib treatment in the past.
• Have bleeding or clotting disorders.
• Have had recent gastrointestinal bleeding or coughing up blood.
• For liver cancer patients: Have had hepatic encephalopathy in the last 6 months.
• For endometrial cancer patients: Have certain types of endometrial cancer.
• Have a severe gastrointestinal or non-gastrointestinal fistula.
• Have an active COVID-19 infection.
• Are male and have not had a vasectomy, and their female partners are of childbearing potential and not using effective contraception.
• Have a psychiatric or substance abuse disorder that would interfere with the study.
• Have any other significant medical conditions that could affect safety or study results.
• Are scheduled for major surgery during the study.