Study on Accelerated Brachytherapy and Chemo Radiation Therapy for Advanced Cervical Cancer
Sponsor: Washington University School of Medicine
ClinicalTrials ID:NCT06529809
This clinical trial is exploring a new approach to treating advanced cervical cancer by combining brachytherapy with a faster schedule of external radiation and chemotherapy. The study aims to see if this method can improve treatment outcomes and reduce side effects.
Patient Parameters
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Program Overview
The study is testing a new treatment method for advanced cervical cancer that combines brachytherapy with a quicker schedule of external radiation and chemotherapy. The goal is to see if this approach can improve how well the treatment works and reduce side effects. Researchers are particularly interested in how this method affects the time it takes to complete treatment, as longer treatment times can lead to worse outcomes. The study will look at how this approach impacts cancer recurrence, survival without cancer returning, and the body's immune response.
Eligibility Criteria
Inclusion Criteria
- Newly diagnosed with advanced cervical cancer (stage IB3-IVA) confirmed by a biopsy.
- Cancer type must be squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix.
- Suitable for radiation therapy as determined by a radiation specialist.
- Must be 18 years or older.
- Must be in relatively good health, with a performance status score of 2 or less.
- Must understand and agree to sign a consent form to participate in the study. A legal representative can sign on behalf of the participant if needed.
Exclusion Criteria
- Have had previous radiation treatment to the pelvic area.
- Have had any other pelvic cancer or gynecologic cancer.
- Have another cancer that could interfere with the study's treatment or results.
- Have cancer that has spread outside the pelvic area or to specific lymph nodes.
- Have had or plan to have a hysterectomy as part of cervical cancer treatment.
- Are pregnant or breastfeeding. Women who can become pregnant must have a negative pregnancy test before starting the study.
- Have had major surgery within the last 3 weeks, unless fully recovered.
- Have serious, uncontrolled health issues, such as heart problems, severe lung disease, or active infections.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| Washington University School of Medicine | 63110 | Saint Louis | Missouri |
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