Study on Anti-HER2 Therapy for Nigerian Women with HER2+ Breast Cancer Before and After Surgery

Inclusion Criteria

• Women aged 18 to 70 years old.
• Have a breast tumor that is at least 2 cm in size and can be measured by ultrasound.
• Diagnosed with HER2-positive breast cancer.
• Cancer is in stages 2A to 3C.
• Have not received chemotherapy for this cancer before.
• In good general health with a performance status score of 0 to 3.
• Not pregnant or nursing, and willing to use hormone therapy and contraception.
• Have adequate blood, kidney, and liver function based on specific lab tests.
• Heart function must be normal with an ejection fraction of 55% or higher.

Exclusion Criteria

• Pregnant or breastfeeding women, or those not using effective contraception.
• Cancer has spread to distant parts of the body.
• Have serious, uncontrolled infections.
• Have received more than 4 weeks of tamoxifen therapy for this cancer.
• Have had other cancers in the last 5 years, except for certain skin or cervical cancers.
• Participated in another drug study within the last 4 weeks.
• Have serious medical conditions that could affect participation, such as uncontrolled infections, HIV, heart problems, or uncontrolled diabetes.
• Not willing or able to follow the study protocol.
• Have HER2-negative breast cancer.
• Have a history of heart failure or certain heart conditions.
• Have poorly controlled high blood pressure.