Study on Using Advanced MRI Techniques to Improve Surgery Outcomes in Glioblastoma Patients

Sponsor: Jonsson Comprehensive Cancer Center

Sponsor score: 40
Inactive

ClinicalTrials ID:NCT06448286

Provider View

This clinical trial is testing whether a new type of MRI scan can help surgeons remove more of the tumor in patients with glioblastoma, a type of brain cancer, compared to the standard MRI scans currently used.

Patient Parameters

Program Overview

The study is exploring a new MRI technique called pH weighted chemical exchange saturation transfer (CEST) MRI, which may help identify tumor areas that standard MRI scans miss. This could potentially allow surgeons to remove more of the tumor during surgery, improving treatment outcomes for patients with glioblastoma. Glioblastoma is a type of brain cancer that is usually treated with surgery, followed by radiation and chemotherapy. The trial will compare the effectiveness of surgeries guided by this new MRI technique to those guided by standard MRI scans.

Description

The main goal of this study is to see if using a new type of MRI scan during surgery can help remove more of the glioblastoma tumor. This new MRI technique, called pH weighted CEST MRI, might show parts of the tumor that standard MRI scans do not.

Patients in the study will be randomly assigned to one of two groups:

  • Group 1: Patients will have surgery using the standard MRI guidance. After surgery, they will receive the usual radiation therapy and take a chemotherapy pill called temozolomide for 6 weeks. They will also have follow-up MRI scans.

  • Group 2: Patients will have surgery using the new CEST MRI guidance. After surgery, they will also receive the usual radiation therapy and take temozolomide for 6 weeks, along with follow-up MRI scans.

After finishing the treatment, patients will have follow-up visits at 3, 6, 12, and 24 months to monitor their health and the effectiveness of the treatment.

Eligibility Criteria

Inclusion Criteria

  • Must be 18 years or older.
  • Have a new diagnosis of grade IV glioblastoma, confirmed by medical tests and imaging.
  • Must provide written consent to participate in the study and be able to follow the study requirements.

Exclusion Criteria

  • Under 18 years old.
  • Have a condition that the study doctor believes could affect safety or data quality.
  • Not cleared medically for surgery.
  • Have had previous treatments like chemotherapy, targeted therapy, immunotherapy, or radiation.

Get This Program In Your Inbox

Receive detailed information about this treatment opportunity to review with your healthcare provider.