Study on Neoadjuvant Chemotherapy for Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria

• Must be 18 years or older.
• Have a confirmed diagnosis of non-small cell lung cancer (NSCLC).
• Cancer must be at a stage that can be surgically removed (stages 1B, 2A, 2B, or 3A).
• Primary tumor must be 3 cm or larger.
• Agree to provide blood samples for research.
• Must be a candidate for surgery.
• Have a performance status score of 0 or 1, indicating full activity or some restriction in strenuous activities.
• No previous treatments like chemotherapy or radiation for the current lung cancer diagnosis.
• Have measurable disease according to specific criteria.
• No active invasive cancer in the past 2 years, except for certain skin cancers.
• Must sign a consent form and agree to the study's privacy guidelines.
• Sexually active participants must use effective birth control during the study and for 120 days after the last dose.
• Women of childbearing potential must test negative for pregnancy before starting the study.
• Must have adequate organ function as shown by specific blood tests.

Exclusion Criteria

• Currently in another study or have been in one recently.
• Have specific genetic mutations related to lung cancer.
• Have a history of active tuberculosis.
• Allergic to alirocumab or its ingredients.
• Receiving other cancer treatments.
• Have had certain immune therapies before.
• Have used an anti-PCSK9 drug recently.
• Have active hepatitis B or C.
• Unable to follow the study procedures.
• Have an active infection needing treatment.
• Have a history of lung inflammation not caused by infection.
• Have uncontrolled HIV, hepatitis B, or C, unless well-managed.
• Have an autoimmune disease needing treatment in the past 2 years.
• Have a diagnosis of immunodeficiency or are on immunosuppressive therapy.
• Have another progressing cancer needing treatment.
• Pregnant or breastfeeding, or planning to conceive during the study.
• Have had major surgery recently, except for lung cancer surgery.
• Have had a live vaccine recently, except for certain flu or COVID-19 vaccines.
• Have had a recent heart attack or have uncontrolled heart issues.
• Have psychiatric or substance abuse issues affecting study participation.
• Are a prisoner or involuntarily detained.