Propranolol for Treating Kaposi Sarcoma in Adults

Sponsor: Washington University School of Medicine

Sponsor score: 40

ClinicalTrials ID:NCT06445166

Provider View

This study is exploring the use of propranolol, a medication, to treat Kaposi Sarcoma (KS) in adults. KS is a type of cancer caused by a virus and is common in some parts of Africa and among people with HIV. The study aims to see if propranolol can help reduce KS lesions and is safe for patients.

Patient Parameters

Program Overview

Kaposi Sarcoma (KS) is a cancer that starts in cells infected by a virus called KSHV or HHV-8. It often leads to abnormal blood vessel growth, inflammation, and uncontrolled cell growth. KS is common in some African countries and among people with HIV, where treatment options are limited. This study is testing propranolol, a drug known for its ability to reduce blood vessel growth, to see if it can effectively treat KS. Researchers believe propranolol could help shrink KS lesions and be safe for patients. The goal is to achieve a response rate of at least 45%, meaning that many patients will see their KS improve or disappear.

Eligibility Criteria

Inclusion Criteria

  • Have a confirmed diagnosis of Kaposi Sarcoma that can be measured.
  • Have at least two KS lesions that are 4x4 mm or larger and can be biopsied.
  • KS should be limited to the skin, lymph nodes, or minimal oral lesions.
  • Be at least 18 years old and weigh more than 40 kg (about 88 pounds).
  • Have a performance status score of 2 or less, meaning you are able to carry out daily activities.
  • If you are HIV positive, you must be on antiretroviral therapy for at least 12 weeks.
  • If you are HIV negative, there should be no improvement in KS in the last 12 weeks.
  • Women of childbearing age must use effective birth control during the study and for one month after.
  • Be able to take oral medication.
  • Be willing to sign a consent form to participate in the study.

Exclusion Criteria

  • Have KS that affects internal organs and causes problems.
  • Need immediate chemotherapy treatment.
  • Have another cancer that could interfere with the study.
  • Currently taking beta-blockers for other conditions.
  • Receiving other cancer treatments or investigational drugs.
  • Have allergies to propranolol or similar drugs.
  • Have asthma or other lung diseases.
  • Have diabetes with high blood sugar levels.
  • Have heart problems like heart failure or low blood pressure.
  • Have symptoms like shortness of breath or bleeding not related to KS.
  • Have uncontrolled illnesses or infections.
  • Be pregnant or breastfeeding.
  • Have hepatitis B or C infections that are not well controlled.

Locations

FACILITYZIPCITYSTATE
Washington University School of Medicine63110Saint LouisMissouri

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