Study on REC-1245 for Patients with Advanced or Spread Cancer
Sponsor: Recursion Pharmaceuticals Inc.
ClinicalTrials ID:NCT06678659
This clinical trial is testing a new oral medication, REC-1245, to see if it is safe and effective for people with advanced or spread solid tumors that cannot be surgically removed.
Patient Parameters
| Parameter | Options |
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Program Overview
The study aims to evaluate the safety and effects of a new drug, REC-1245, taken once daily by mouth, in patients with advanced or metastatic solid tumors that cannot be removed by surgery. Researchers will monitor how the drug is processed in the body and its initial effects on the cancer.
Description
This study involves about 85 participants and is divided into two phases. In Phase 1, 55 participants will be enrolled to assess the safety and how the body processes the drug. In Phase 2, 10 to 30 participants will be further evaluated for the drug's effects on their cancer. Participants will take REC-1245 daily for up to two years, and researchers will closely monitor their health and the drug's impact on their cancer.
Eligibility Criteria
Inclusion Criteria
- Must be 18 years or older.
- Have a confirmed diagnosis of advanced or metastatic solid tumors or certain types of lymphoma that cannot be surgically removed.
- Have tried at least one standard cancer treatment that did not work or were unable to receive standard treatment.
- Be in good overall health with an ECOG performance status of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
- Have measurable cancer as determined by standard imaging tests like CT or MRI.
Exclusion Criteria
- Have previously received treatment with another drug similar to REC-1245.
- Have significant digestive system issues that affect the absorption of medication.
Locations
| FACILITY | ZIP | CITY | STATE |
|---|---|---|---|
| City of Hope | 91010 | Duarte | California |
| Cleveland Clinic | 44195 | Cleveland | Ohio |
| SCRI Oncology Partners - PPDS | 37203 | Nashville | Tennessee |
| START Mountain Region | 84119 | West Valley City | Utah |
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