Study on Melphalan With or Without Siltuximab for Multiple Myeloma Patients Undergoing Stem Cell Transplant

Inclusion Criteria

• Diagnosed with symptomatic multiple myeloma and planning to undergo a stem cell transplant within 12 months of diagnosis.
• Aged 60 years or older.
• Have enough stem cells available for the transplant.
• Be in relatively good health, with a performance status score indicating the ability to carry out daily activities.
• Meet specific lung and heart function criteria based on medical tests.
• Have certain blood counts and liver and kidney function within specified limits.
• Women must be postmenopausal or otherwise not able to become pregnant.
• Men must agree to use birth control and not donate sperm during the study and for three months after the last dose of the study drug.

Exclusion Criteria

• Previous treatment with drugs targeting IL-6 or its receptor.
• Other active cancers within the past two years, except for certain skin cancers or early-stage cervical cancer.
• Medical conditions that could interfere with the study or pose a risk to the participant.
• Recent heart issues requiring treatment or uncontrolled heart conditions.
• Recent vaccination with live vaccines.
• Significant infections, including HIV or hepatitis, unless well-controlled.
• Participation in another investigational study or recent use of investigational drugs or devices.
• Recent hospitalization for infection or major surgery, unless fully recovered.
• Men planning to father a child during the study or within three months after the last dose of the study drug.