Study on the Safety and Effects of Epidiferphane and Taxane Chemotherapy in Breast Cancer Patients

Inclusion Criteria

• Must be 18 years or older.
• For Phase I: Starting chemotherapy for breast cancer or diagnosed with metastatic breast cancer.
• For Phase II: Diagnosed with breast cancer at any stage.
• Starting a new treatment with specific chemotherapy drugs (paclitaxel, docetaxel, or nab-paclitaxel) at UF Health.
• Must have a performance status score of 3 or less, indicating ability to perform daily activities.
• Must continue cancer treatment at UF Health for at least three months.
• No more than one active cancer at the time of joining the study.
• Must have a working digestive system without blockages.
• Must avoid regular green tea and curcumin supplements during the study.
• Must provide written consent and be able to follow study procedures.
• Women of childbearing age must use effective birth control during the study.
• Men with partners of childbearing age must agree to use effective birth control methods.

Exclusion Criteria

• Cannot be taking other experimental drugs.
• Women who are pregnant or breastfeeding cannot participate.
• Must not have any serious infections at the time of treatment.
• Cannot have psychiatric or social issues that would prevent following the study requirements.
• Must not be allergic to turmeric, broccoli, or green tea.
• Cannot be taking certain medications that interfere with the study drugs.
• Must not have any other health conditions that could complicate treatment or affect study results.
• Cannot be in prison or involuntarily detained.
• Must not have severe nerve damage or liver issues.
• Must not have had a blood transfusion within 30 days before starting treatment.