Study on Using Reduced Intensity Conditioning and Post-Transplant Cyclophosphamide for Blood Disorders

Sponsor: Masonic Cancer Center, University of Minnesota

Sponsor score: 40

ClinicalTrials ID:NCT05805605

Provider View

This clinical trial is exploring a new approach to stem cell transplants for patients with blood disorders, using a less intense preparation method and specific medications to prevent complications after the transplant.

Patient Parameters

Program Overview

This study is testing a new method for stem cell transplants in patients with blood disorders. It uses a less intense preparation process, including medications like cyclophosphamide, fludarabine, and total body irradiation, followed by a stem cell infusion from a related, unrelated, or partially matched family donor. After the transplant, patients receive medications to prevent complications, including post-transplant cyclophosphamide, sirolimus, and MMF.

Eligibility Criteria

Inclusion Criteria

  • Ages 0 to 75 with good overall health scores.
  • Must have a suitable donor match for stem cell donation.
  • Eligible diseases include certain types of leukemia, lymphoma, and other blood disorders.
  • Must be in remission or have specific disease characteristics.
  • Adequate organ function, including liver, kidney, heart, and lungs.
  • Must not have active infections or uncontrolled health conditions.
  • Women of childbearing potential and men with partners of childbearing potential must agree to use birth control during the study.
  • Must provide written consent to participate.

Exclusion Criteria

  • Pregnant or breastfeeding women.
  • Untreated active infections.
  • Active cancer in the central nervous system.
  • Certain aggressive blood cancers that are not responding to treatment.
  • Less than 3 months since a previous intense transplant.
  • Evidence of disease progression on scans or biopsies.

Locations

FACILITYZIPCITYSTATE
Masonic Cancer Center at University of Minnesota55455MinneapolisMinnesota

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